How not to clot
نویسندگان
چکیده
منابع مشابه
When the brain tells the blood how to clot.
In this issue of Blood, Tian et al report that during traumatic brain injury, small membrane vesicles, called microparticles, disseminate procoagulant factors from the brain into the systemic circulation. The delivery appears to occur through the disrupted blood-brain barrier.
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BACKGROUND Acute coagulopathy of trauma (ACOT) has been described as a very early hypocoagulable state, but the mechanism remains controversial. One proposed mechanism is tissue hypoperfusion leading to protein C activation, with subsequent inhibition of Factors V and VIII. Variability in trauma has impeded the use of clinical data towards the elucidation of the mechanisms of ACOT, but thrombel...
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ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2001
ISSN: 1471-0072,1471-0080
DOI: 10.1038/35096000